A clue to the onrush of safety difficulties can be found in an event in March , 1979
ANY journalist working in a war-torn or politically unstable region knows the risks and headaches of the job: threats to personal safety, difficulties of access, interference from authorities.
Current protocols for human pluripotent stem cell (hPSC) expansion require feeder cells or matrices from animal sources that have been the major obstacle to obtain clinical grade hPSCs due to safety issues, difficulty in quality control, and high expense.
From the model results, it has been concluded that perceived safety, crossing difficulty, land-use condition, number of vehicles encountered, median width and number of lanes have significant effect on pedestrian perceived LOS at unprotected (un-signalized) mid-block crosswalks in mixed traffic scenario.
Conversion to open colectomy was at the discretion of the surgeon based on concerns regarding patient safety, technical difficulties, or associated unexpected conditions requiring treatment by laparotomy.
The reluctance to travel beyond the immediate locality owing to fears about safety or difficulties with language created access problems for some first generation participants.
Although percutaneous angioplasty and stent implantation for intracranial atherosclerotic stenotic disease is a widely performed therapeutic option, procedural safety, technical difficulties, and the high rate of recurrent in-stent lesions remain a problem.
Current ESD methods and devices have limitations, including long procedure times, technical difficulty, safety, and availability.
However, these devices have 2 main shortcomings: restriction to backward motion limiting recovery from an overturning wheelchair, which is a safety concern; and difficulty in engaging/disengaging the device while on the ramp.
Contributing to the relatively underdeveloped body of healthcare research focused on workarounds, given their influence on patient safety, is the difficulty in investigating them.
