In order to obtain efficacious and safe compounds, it is necessary to address the issues of potency and selectivity.
For this reason the search of new epigenetic modulators continues focusing on novel, selective, and safer compounds.
The hydroxyl groups present in dextran offer many sites for derivatization, and these functionalized glycoconjugates represent a largely unexplored class of biocompatible and environmentally safe compounds.
In addition, we outline the current therapeutic approaches designed to substitute nicotine from cigarette smoke with safer compounds or to relieve symptoms of nicotine withdrawal during smoking abstinence.
This SMARTS string furthermore showed to be the most significant descriptor in the decision tree approach from which guidelines for the design of safe compounds are suggested.
A promising alternative to antibiotics are organic acids, which include short-chain fatty acids (SCFA), which are "generally regarded as safe" compounds with one or more carboxyl groups and less than six carbons in their molecular formula.
Structure-guided design of inhibitors of thrombin (factor IIa, fIIa) and factor Xa (fXa) eventually led to the discovery of potent, selective, efficacious, orally active and safe compounds that proved successful in clinical studies.
This new information about the mechanism of action of these xenobiotics will assist in improved molecular design with a view to providing safer compounds for use in the (human) environment.
"Better, safer compounds are the way out of this," Maxey says.
Therefore, alternative treatments with safer compounds are needed.
