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Albumin may indeed be safe when used as a resuscitation fluid (as shown by the SAFE study), but our results suggest that it may not be safe all of the time in all critically ill patients.
In the largest RCT conducted to date on albumin administration in critically ill patients (the Saline versus Albumin Fluid Evaluation (SAFE) study), albumin 4% was proven to be safe in terms of mortality and severe AKI compared to crystalloids [ 4].
The large SAFE study reported that 4% albumin was as safe as normal saline in a heterogeneous group of ICU patients [ 49] and meta-analyses have noted that albumin has a better safety profile than other colloid solutions [ 84, 85].
Finally, at least for critically ill patients, with the publication of the Saline versus Albumin Evaluation (SAFE) study, we have conclusive evidence that in the short-term albumin is at least as safe as saline for resuscitation [ 14].
Where school attendance is compulsory, communities have a moral obligation to provide a safe study and work environment.
However, Lung Safe study was not specifically focused on PP.
The LUNG SAFE study was supported by the ESICM.
The LUNG SAFE study was an international, multicenter, prospective cohort study [8].
Five hundred people were enrolled in the SAFE Study over a two year period and randomized to either treatment or control.
The ASTEROID study is an ancillary study, which had been designed and approved by the steering committee of the LUNG SAFE study before the enrollment period began.
Conclusions: We found less mortality than reported in LUNG SAFE study for moderate ARDS and observe and association between mortality and high white cell.
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