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Besides, such an bridge between the two formalisms could, in the case of ERTMS equipment development, help the implementation of safe by design sotware solutions.
We conclude with the strategies leading to safe by design carbonaceous nanoparticles with optimized characteristics for mechanism-based targeted delivery and regulatable life-span of drugs in circulation.
In this paper, we present the design, specification, and implementation of a programming language and a runtime system for wireless sensor networks that are safe by design.
However, in the United Kingdom, the supply law requires manufacturers and suppliers to ensure that machinery as supplied to the user is safe by design as far as practicable, safe to use through the integrity of its safeguarding measures, and is in compliance with the applicable directives.
This knowledge is essential for risk assessment and safe by design approaches in nanotechnology.
Therefore, by regulating the solubilization of silver nanostructures, for example, by applying different coatings, it is possible to fine-tune the nanostructures towards higher toxicity, that is, to yield more efficient silver-based antibacterial agents, or, on the contrary, to render them less soluble if the main goal is other than antibacterial application (safe by design approach) [ 35].
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Based on combined toxicological data, we follow a "safe-by design" strategy for our superparamagnetic iron oxide nanoparticles (SPION).
This study does not say whether the uncoated nanoparticles are actually harmful inside a human body, but the researchers point out that a safer-by-design approach will reduce any possible risks.
More research is required to provide insight in the distribution and toxicity of nanoparticles to aid the development of safe-by-design guidelines for manufacturers [13, 14].
Before their application, the assessment of their potential impact to the target environment cannot ignore the safe-by-design approach.
Knowledge of the special structural features of nanomaterials determining the adverse effects on living organisms is a pre-requisite for the so called "safe-by-design" approach for a directed design of nanomaterials without negative environmental side effects [131 133].
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