Overall, NAC treatment appears to be safe and tolerable.
Local administration of sirolimus, either intravitreally or subconjunctivally, appears to be safe and tolerable.
Additionally, the first-in-human study also yielded positive results and marked idarucizumab safe and tolerable in healthy males [22].
This proof-of-concept study shows that virtual-reality-based neurocognitive interventions are feasible, safe, and tolerable for critically ill patients.
In addition, preoperative DCF chemotherapy has been reported to be safe and tolerable in patients with locally advanced esophageal cancer [3].
Subsequent experience in 50 100 pain patients employing modern neurosurgical techniques was more favorable and demonstrated septal stimulation to be safe and tolerable.
We concluded that salvage gemcitabine in this dose and schedule is safe and tolerable in previously platinum-treated patients with NSCLC.
The main goal of early phase drug development is the demonstration of substantial target engagement at doses which are safe and tolerable and the determination of a therapeutic dose range.
The fundamental requirement of any new molecule is that it is able to reach its site of action in pharmacologically meaningful quantities, at doses which are generally safe and tolerable.
Our results indicate that this virtual-reality-based neurocognitive intervention is feasible, safe, and tolerable for critically ill patients (including mechanically ventilated patients) and that the exercises used provide cognitive stimulation.
The results in this proof-of-concept study suggest that a virtual-reality-based neurocognitive intervention is feasible, safe, and tolerable, stimulating cognitive functions and satisfying critically ill patients.
