Emerging evidence indicates that intense exercise at later stages post-TKR is safe and promotes substantial functional recovery [ 14– 17].
Several trials have indicated such vectors are safe and can induce substantial immune responses against pathogens such as HCV (Barnes et al., 2012, Colloca et al., 2012).
Because we need something real and substantial, something safe, and something not very expensive," he said with a chuckle.
At present, because of the relative novelty of the field, the challenges that need to be overcome in order to develop useful biomarkers and safe and effective interventions are substantial.
Applying this treatment schedule, several clinical studies have documented that neoadjuvant therapy with BV is a safe and feasible treatment, without substantial increase in perioperative morbidity after resection of colorectal liver metastases (D'Angelica et al, 2007; Reddy et al, 2008; Okines et al, 2009).
A discussion of the results generated the hypothesis that the new national essential medicine policy that promoted a better access to medicines and single-use injection devices had made an important and substantial contribution to safer injection practices [ 8- 10].
Within NASA, the cultural impediments to safe and effective shuttle operations are real and substantial, as documented extensively in this report.
The results of this study showed that apatinib was safe and well tolerated, and exhibited substantial antitumor activity at the dose of 750 mg once daily.
However, as well as a 1.5% tax on billionaires, we need an urgent and substantial windfall tax to reduce their wealth to a safe level.
Our observations and our optimization approach have substantial implications for designing safe and effective artificial transcription factors for cell-based and therapeutic uses.
