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Thoracic, lumbar, and sacral spinal cord injuries may result in paraplegia (weakness or paralysis in the legs) and cause dysfunction of the bladder, bowel, and sexual organs.
The projections of the postsynaptic dorsal column neurons in the sacral spinal cord ascend near the midline of the dorsal column, as predicted from the clinical results.
Spinal nerve roots emerge via intervertebral foramina; lumbar and sacral spinal roots, descending for some distance within the subarachnoid space before reaching the appropriate foramina, produce a group of nerve roots at the conus medullaris known as the cauda equina.
Mice were perfused 2 h after injection and major anatomical regions of the CNS were dissected (striatum, midbrain, cerebellum, hippocampus, cortex, olfactory bulb, brainstem, and cervical, thoracic, lumbar and sacral spinal cord).
The decision to switch from storage to voiding modes depends upon integrating, in the central nervous system, sensory information from the bladder and controlling lower urinary tract function from the sacral spinal cord.
He has a condition called Lumbar Sacral Spinal Agenesis Congenital Paraplegia.
Similar(25)
Furthermore, immunohistochemical analysis revealed that a higher axonal density in lumbo-sacral spinal cords could be demonstrated only in the trichostatin A treated group [ 77].
Our study was aimed at revealing presence of neurons within RVL supplying branching collateral input to the medial preoptic area (MPA) and to the lumbo-sacral spinal cord (SC-L) in the rat.
Spinal reflex pathways not only enhance sympathetic outflow but also α-motoneuron discharge from Onuf's nucleus in the ventrolateral horn of the sacral (S2 S4) spinal cord [ 12].
The preganglionic parasympathetic fibers arise from the intermediolateral cell column of the sacral (S2 S4) spinal cord to form pelvic splanchnic nerves.
Positive immunostaining was localized throughout each division (cervical, thoracic, lumbar and sacral) of the spinal cord; however, regions immediately adjacent to the central canal of the spinal cord or to the subarachnoid space surrounding the spinal cord displayed the highest intensity of staining (Figure 1a, S6).
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