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Based on our findings, we believe that several outcomes add to current body of knowledge regarding running intensity and pacing during competitive circumstances.
However, the relationship between running intensity and the induced loading on cartilage should be clarified in the future study.
Given that one of the fitness tests is completed at maximum running speed, the running intensity is much higher during fitness testing.
Our study, for the first time, investigated the effect of running intensity, expressed as percentage of VO2max, and an intensity-dependent effect was suggested on the articular cartilage.
As suggested by the current study, running-induced joint loading has significant effects on the in vivo synthesis of lubricin, and such effects vary with running intensity.
Running intensity was set corresponding to maximal lactate steady state (MLSS), previously identified in obese Zucker rats [ 28] and SHR rats [ 27].
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Galois et al.[ 7] investigated whether different running intensities influenced osteoarthritis (OA) progression and found that moderate running protected against OA development in anterior cruciate ligament-transected knee joints.
This could be explained by the increased number of physical collisions and RHIE bouts performed by the high-standard group, which are overlooked by simply assessing match running intensities.
The total running and non-weight-bearing training load is usually progressed based on standard weekly training distances and high-speed running intensities.
Ploughman et al. [ 20] compared hippocampal BDNF levels between a forced 60-minute motorized run (higher intensity) and 12 hours of voluntary wheel running (lower intensity) over a two-week duration in animals that had been exposed to ischemic injury.
Wistar rats, without previous lesion in the knee, have also been randomly assigned to a sedentary control group, a low-intensity running, a medium-intensity running, and a high-intensity running [18].
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