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However, neither Purdue Pharma nor any drug producer has ever run significant studies to assess the long-term benefits or risks of the medications.
My noble Lord: over the past few weeks the Observer has run significant pieces on race in Britain, the scandal of child abuse in deaf schools, heavyweight election coverage, the truth about the Guantanamo Bay detainees, Belmarsh uncovered, articles in memory of Auschwitz and - this week alone - two major pieces of investigative journalism.
The two most powerful heiresses already run significant businesses.
"It's not like we called them from central casting," she added, noting that Holt, Hornsey and Whetstone really do run significant aspects of the day-to-day business at the ride-hailing company.
Federal Reserve Bank of New York officials scrambled to do damage control in the days after their $180 billion rescue of American International Group in September 2008, including an effort to control information by asking AIG to run significant outside communications through the Fed's outside counsel.
In eight participants, who successfully completed the half (n = 4) or full (n = 4) marathon run, significant post-race increases occurred in levels of (1) suPAR, a biomarker of immune activation; (2) CD163, a biomarker of monocyte-macrophage activation; (3) CRP, a biomarker of acute phase response; and (4) pro- (IL-6, IL-8) and anti-inflammatory (IL-10) cytokines.
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In the 1990s it consistently ran significant budget deficits while using the Drachma.
It should be remembered that we ran significant deficits even when the economy was growing in the 2000s.
On the latter point: traditionally, the U.S. government ran significant budget deficits only in times of war or economic emergency.
The theater is responsible for supporting itself through contributions, grants and ticket sales, but in recent years it ran significant deficits, which the university's arts division covered.
Pregnant smokers who take up e-cigarettes as a healthier substitute for tobacco may still be running significant risks with the wellbeing of their unborn children.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com