S100 family of proteins including S100A7 have been shown to form both homodimers and heterodimers interacting with cjun activation domain binding protein 1 (Jab1), Ran binding protein M (RanBPM), epidermal fatty acid binding protein (EFABP), and transglutaminase.
RanBP2, a Ran binding protein with four Ran binding domains, is a major cytosolic component of filaments that are derived from the cytoplasmic ring of the NPC during interphase.
Plant Ran binding proteins (RanBPs) display significant homology with yeast and mammalian RanBPs, but there is little evidence for their biological function [ 6, 7].
Guanine nucleotide binding protein (AGB), Annexins (ANNATs), ABA responsive protein (RAB), Ran binding protein (RANBP), Auxin induced protein and Zinc binding dehydrogenase are classified under this category (Additional file 5).
These include homodimerization [ 34], and interactions with c- jun activation domain binding protein 1 (Jab1) [ 19], Ran binding protein M [ 35], epidermal fatty acid binding protein [ 36], and transglutaminase [ 37].
LIM and senescent cell antigen-like domains 1 (LIMS1) and Ran binding protein 2 (RareP2) are closely located on chicken chromosome 1 and were both expressed in higher amounts in RJ (Table 2).
We found exportin 1 (XPO1) which interacts with EIF5A [ 34], NUP214 [ 35], NXF3 [ 36], ORC1 [ 37], Ran binding protein 2 [ 38], DDX3 [ 39], Survivin [ 40], and telomere reverse transcriptase [ 41].
Similarly, Yrb2p (yeast ran binding protein 2; a.k.a. Nup36p) is primarily nuclear, but contains FG repeats, yet it only transiently associates with the NPC (Floer and Blobel 1996).
Ras-related nuclear proteins (Rans) are abundant small GTPases, associated with Ran-specific nuclear GEFs (guanine nucleotide exchange factors), cytoplasmic GAPs (GTPase activating proteins), and with RanBP1 (Ran binding protein 1) that stimulate RanGTP hydrolysis in the cytoplasm [ 1, 2].
Given that the regulatory functions of Ran are mediated by the dissociation of importin β1 complexes and that importin β1 also localizes at the mitotic spindle and spindle pole region, we hypothesized that the contribution of RanBP2 (a Ran binding protein) is to spatiotemporally regulate the recruitment of importin β1 during mitosis.
The G-run-binding factor hnRNP H is known to participate in exon definition [ 27, 28].
