As America grew more insistently democratic, and populist, the ruling campaign model began to change as well.
Our experiments have now shown that the latter is clearly the case, lending support to models A and B, and effectively ruling out models C and D. Hence, despite their interaction, Rad18 and Rad5 do not follow the strategy of heterodimeric RING E3s such as the BRCA1 BARD or the RING1b BMI1 complex, where activity depends on dimerisation (Hibbert et al, 2009).
Limping was equally unaffected by mutations that produced 50-fold changes in stalk stiffness, ruling out models where limping arises from an asymmetry in torsional strain.
Earlier this year, it was suggested in a judge's high court ruling that the model and TV presenter Imogen Thomas had been guilty of blackmailing a high profile footballer.
And, in August, a federal judge named Claudia Wilken challenged the entire amateur model, ruling that the N.C.A.A. had been artificially restraining trade by capping what schools could pay their student athletes in revenue sports like football and men's basketball.
According to the ruling, Crocs' Beach model shoes "lack individual character" compared with other similar brands.
Tim Golby, the council's lead on social care commissioning, said the ruling showed the model used to calculated the increase was "fair and appropriate".
Thus, transport of the LC3 fusion proteins into and out of the nucleus occurs more slowly that than of EGFP under steady state conditions, ruling out a model in which rapid passive transport contributes significantly to its steady state distribution.
In contrast, no difference in infiltrate was observed in our model, ruling out the possibility that tissue degeneration is caused by autoimmunity.
This figure also demonstrates how the uncertain category (labelled 'Medium') would be reduced by 82% if physician estimates were combined with a model ruling out pneumonia when PCT values were <0.25 ng/mL.
