Furthermore, development and testing of computational rules governing the precise mechanism of translational regulation of MoTTs is needed to identify the most significant regulatory regions where modifications regulate the translation of specific transcripts.
On the other hand, although our results exclude major transcriptional modifications of p16INK4a in primary tumours, we cannot rule out the possibility of translational or post-translational changes that could explain the high proportion of NB with lack of p16INK4a immunostaining in the series reported by Takita et al (1998).
An exception to this general rule is in the field of translational genomic research, which uses the results of preclinical studies to validate new research tools and methods for diagnostic, prevention, and treatment, and the occasional cases of actionable research results or material incidental findings from GWAS and whole-genome/exome studies.
Moreover, these rules are produced by either strong genomic dinucleotide bias against UpA (Figure 6B, rule D) or by rejection of error prone UA-rich codon-pair contexts in coding sequences (Figure 6B, rule F), in a clear confirmation of the additive effect of translational and non-translational selective pressures.
Our results are consistent with this notion, although do not rule out that miR-130a may also target other messages for degradation instead of translational inhibition as seen with the FOG-2 3'UTR.
Thus, while we identify more instances of translational control than all prior studies, these instances appear to be the exception, and not the rule, as the vast majority of genes appear to lack overt translational control as measured by this assay.
Dr. Swain was the school's dean of translational medicine — the specialty of turning laboratory discoveries into practical drugs or therapies.
Many of my colleagues are uneasy at the thought of translational research, not least because governments around the world are funnelling increasing amounts of money into such projects.
There is also renewed talk about the importance of "translational"' research that brings the users and producers of research together in creative alliances.
