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In addition to reducing design time to minutes, GenoCAD improves the quality and reliability of the finished sequence by ensuring that the designs follow established rules of sequence construction.
In general, it is not practical to anchor unmapped genes or sequences by contig assembly with STS sequences because of both the limited number of the STSs in the integrated map and the end-by-end detection rules of sequence contig assembly.
The high level of agreement is explained by the basic finding that the splicing ratios follow the basic rules of sequence preferences seen for isolated 3' splice sites: position -3 with C ≥ T > A > G, position +1 with G ≥ A > T > C (data not shown).
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We further investigate the synchronization between molecular evolution and macroevolution to search for evolutionary rules of sequences corresponding to structures of MCF in order to determine the characteristics of structural changes.
For purposes of sequence comparison with BLAST, a thorough match was conservatively defined (Supporting Information) as to be far more stringent than the informal 3% rule of sequence dissimilarity sometimes evoked for species delimitation among bacteria and other organisms [20] [21].
To eliminate this bias effect caused by homologous proteins in the polypharmacology analysis, we have conflated the homology target proteins into their specific families according to rule of sequence similarity ≥ 30% to build a modified drug-target network.
Furthermore, a faulty phase recognition method is proposed based on the variation rules of zero-sequence voltage on faulty condition.
Corollary 8 All solutions of the equation x 2 − L 2 n x y + y 2 = − F 2 n 2 are given by ( x, y ) = ∓ ( F 2 n + 2 m + 1, F 2 m + 1 ) with m ∈ Z. Now, let us examine all solutions of the following equations by using Diophantine equations given in Theorem 11, Theorem 12, Theorem 13 and the divisibility rules of the sequences ( u n ) and ( v n ).
In particular our results suggest the following rules for sequence correction of SNP probe intensities: Sequence effects due to WC pairings between probe and target are well approximated using nearest-neighbor (NN) motifs in analogy with accepted NN-free energy models for oligonucleotide-duplexing in solution [33].
To determine the genomic structure of the human cortactin gene, an algorithm was applied based on the consensus sequence of exon-intron junctions ('gt... ag' rule of intronic sequence) as well as on the codon usage within ORF.
With these clones, we determined all exon/intron boundaries and size of all introns and exons (Table 2A) of the human cortactin gene by (1) performing BLAST comparisons with the cDNA against the genomic DNA and (2) using the GeneFinder program [ 60] based on the consensus sequence of exon-intron junctions ('gt... ag' rule of intronic sequence) as well as on the codon usage within ORF [ 61].
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