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They could rule out a model which assumes that the desorption starts at the surface, forms a growing metal shell and a shrinking hydride core.
While we cannot rule out a model whereby Lmna−/− cells have increased gankyrin mRNA stability and not transcription, our findings add to the growing evidence that lamin A/C, either directly or indirectly, is important for regulating a subset of genes at the transcriptional level [14], [20], [54] [56].
While our data showing that axin is excluded from APC-rich protrusions suggests that phospho-β-catenin is not always targeted for proteasomal-mediated destruction, we cannot rule out a model whereby phosphorylation of β-catenin earmarks the protein for destruction by non-axin-mediated mechanisms.
From our analysis, however, we cannot rule out a model in which two independent fusion events of the ψErv/Erv unit with either a single Trx domain or tandem Trx domains led to the set of contemporary QSOXs.
The finding reported here does not rule out a model in which there is a common upstream regulator of CENP-A, p16INK4A, and possibly other proteins that play a role in age-related replicative decline, but the fact that p16INK4A is transcriptionally regulated while the decline in CENP-A appears to be post-transcriptional suggests that multiple mechanisms may be operative.
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For intestinal crypts, our analysis thus rules out a model of tissue homeostasis in which lost cells are replenished by a single dominant cell that divides only assymetrical.
These observations also seem to rule out a simple model of clathrin coat activation that could be based on changes in the physical properties of the lipid bilayer at the site of coat formation due to local clustering of glycosphingolipids induced by binding to the pentameric StxB.
Our results rule out a simple model in which nuclear Argonaute protein-associated-small RNAs are sufficient to trigger germline nuclear RNAi responses.
In particular, the database workload and cloud instance performance are stochastic variables [33 35] which meant we ruled-out a model transformation/query to obtain results directly from the models.
"Even if the magnetar energy limit is not strictly violated, the tremendous efficiency required by this process strains credulity". "In the future, we will be trying to make more precise measurements and be looking for more events to rule out a neutron star model," Cenko said.
In conclusion, the mathematical arguments that were previously developed are insufficient to rule out a size-independent, timer model of bacterial division: quantitative comparisons between models and data are needed.
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