That comfortably rugged space, which presents the occasional jazz outlier among rootsier fare, held a jam-session relief drive on Thursday, soliciting cleanup supplies like buckets and bleach.
Our overall aim is to provide general guidance that should help users at any level, from novice to expert, to safely navigate through the rugged space of directed AAV evolution while avoiding the pitfalls that are associated with these challenging but promising technologies.
He looks as if he could use a chanting session at the impressive altar in the living room alcove, one of the few spots in this rugged 2,000-square-foot 2,000-square-foot 2,000-square-footoftened by kilim rugspace
Still, I suppose we all love a mystery, and when rugged, unsmiling space scientist Dr Christian King suddenly started getting disturbing images streaming live on to the conveniently huge screens in his office, well, who wouldn't call the police?
Concerned that the expansion could adversely affect, or eat into, 7,000 adjacent acres of rugged open space, the group recently persuaded the Sierra Club to cite Stewart as New York State's worst example of sprawling development.
Application of advanced methods such as replica exchange Monte Carlo to sample the rugged energy spaces of proteins, and graph manifold learning to analyze the vast structural spaces of the molecular ensembles that constitute them, should prove useful for a variety of ab initio approaches to structure prediction, genome annotation, and drug design.
Thus, they are more robust, and hence appropriate, for problems with rugged parameter spaces.
But even for this rugged, unruly place, the murders, in the space of three days, of three American missionaries and an opposition party leader are deeply disturbing.
El Paso lies in a narrow space between rugged mountains and the Rio Grande.
However, as in reality the model's landscape is not entirely smooth, it is crucial to map rugged regions across chemical space, since identifying these regions is the only way of assuring that the model is being safely used for future predictions [41.] The applicability domain establishes where the QSAR is smooth (i.e., where the dependency between structure and property holds).
We explicitly show that the landscape of the cost function used to optimize the model to the data has a very rugged surface in parameter space.
