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Our studies implicate Prickle1 in regulating Wnt/PCP pathway and provide novel insights into RS disease mechanism.
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In total there were four pre-chemotherapy cell lines derived from primary disease (TOV1369, OV2295, TOV3133G and TOV3133D) and five post-chemotherapy cell lines derived from recurrent (R) disease (OV1369(R2), OV2295 R2), TOV2295(R), OV3133(R) and OV3133 R2)).
No significant correlations between MRI measures and UMN, ALSFRS-R, disease duration, or progression rate were found in either group of patients, nor for both groups combined (Table II).
Clinical status of the patients was evaluated using the ALS Functional Rating Scale-Revised (ALSFRS-R) and disease progression rate was assessed (48 - ALSFRS-R-score/disease duration (months)).
The prognostic value of advanced age as a harbinger of CHIK-R at disease onset has gained attention since the seminal description of CHIK-R [ 20, 21].
Softshelled turtle iridovirus (STIV) is the first Asian iridovirus isolated from reptiles, which infects soft-shelled turtles severely and leads to "Red neck disease" associated with high mortality.
Progression rate was calculated as: (48 minus ALSFRS-R)/(disease duration).
cc: cluster coefficient; Btwn: betweenness, Red circle: disease miRNA; Green circle: disease TF.
The characteristics and the localizations of CHIK-R at disease onset in this population are presented in Table 1.
Enteric Red mouth Disease (ERM), caused by Yersinia ruckeri, is one of the most important infectious diseases in rainbow trout (Oncorhynchus mykiss) aquaculture in Europe.
Red leg disease is common.
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