State Route 2, and the Lincoln Highway, used a different routing between Ely and Salt Lake City, Utah from the modern routes.
AASHTO policy says that a toll road may only be included as a special route, and that "a toll-free routing between the same termini shall continue to be retained and marked as a part of the U.S. Numbered System".
The former routing between Wyoming and Chisago City along Constitutional Route 46 was then redesignated MN 98 until it was decommissioned in the late 1990s.
By 1938, SR 85 was truncated to its current routing between Andover and the connection to Pennsylvania Route 285 on the Pymatuning Causeway, leaving US 6 to be the lone route running between Euclid and Andover.
The highway was moved to a new routing between Flint and Lapeer in 1929; the old route was renumbered M-21A.
In 1910, Route 26 was realigned to follow a more direct routing between Little Falls and Remsen via Middleville and Poland.
US 4's former routing between Glens Falls and Hudson Falls became part of NY 32B, a new route assigned in the renumbering that continued south to NY 32 in Northumberland by way of an overlap with US 4.
Two realignments in the 1930s moved the route onto its modern alignment, and NY 78's original routing between East Aurora and Depew was briefly designated NY 78A during the mid-1930s.
The overlap between NY 12D and NY 26 remained in place until the 1970s when NY 12D was realigned onto its current routing between Potters Corners and Lyons Falls, replacing then-New York State Route 337.
In the early 1950s, NY 365's old routing between Harrietstown and Gabriels was designated as NY 192A, a spur route of NY 192.
Starting around the year 1955, US 8 was moved to a more direct routing between Forest Lake and Chisago City; US 8 replaced MN 98 along Legislative Route 98.
