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However, several problems have still to be solved before CFD can routinely be applied in product development.
While de novo protein design remains a challenging problem, R osetta can routinely be applied when searching for thermo-stabilizing mutations, when redesigning protein−protein interfaces, and when performing in silico mutagenesis studies such as alanine scanning.
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High-throughput sequencing of B and T cell receptors is routinely being applied in studies of adaptive immunity.
Hitherto, cluster analysis has routinely been applied to T-RFLP data [ 29- 32], shown in Figure 1.
In studies of postcopulatory sexual selection, paternity success at birth has routinely been applied as a measure of male fertilisation success and sperm competitiveness.
The system screens one 96-well plate within 10 min, has routinely been applied by Novartis, and has resulted in a number of lead compounds [ 62].
150 High-throughput sequencing technologies are now routinely being applied to a wide range of topics in biology and medicine, allowing scientists to address important questions and reveal difficult discoveries that were impossible before.
The sequencing and in-silico analysis of messenger RNA (metatranscriptomics) is now routinely being applied to complex microbial communities in diverse eco-systems, including, but not limited to: soil [ 1– 3], marine [ 4– 6] and intestinal [ 7, 8] habitats.
16, 17 If suitable performance is revealed, the CSI might then be used routinely and also be applied in other geriatric settings.
The same approach can be applied routinely at work.
The analysis method is robust and can be applied routinely.
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