All data were processed using custom-written Matlab routines (version 7; Mathworks, Inc., Natick, MA).
Heritability and genetic correlations were estimated by variance component models using SOLAR (Sequential Oligogenic Linkage Analysis Routines, version 4.1.5), a computer package designed for variance component and linkage analysis in pedigrees of arbitrary size and complexity (Almasy & Blangero 1998).
Figure 2 HBV-light response routine "standard version using UZL and K 0 in SUZ -box" (from HBV-light help, modified).
The signature document provides information about the execution environment, the input and output parameters, a unique name of the library routine, a version number, and a natural language description of the routine.
In AMADEUS-1, participants were unaware they were being studied when they accessed routine practiceoramodified version of it.
If applicable, band densities corresponding to free, singly and doubly bound nucleosomes were quantified using ImageJ software package and subsequently fitted together to a 2 1 binding model using in-house written MatLAB routine (MATLAB version 7.13.0, The MathWorks Inc., Natick, MA).
All statistical analyses on related individuals were conducted using variance component-based methodology implemented in the Sequential Oligonucleotide Linkage Analysis Routines (SOLAR) version 4.0.6 software package (Southwest Foundation for Biomedical Research, San Antonio, TX, USA) [27].
BRTs were constructed using the routines gbm version 1.5 7 [61] and gbm.step [46] in the R statistical program version 2.6.2 (R Development Core Team, http://www.r-project.org).org
Both heritability and genome-wide linkage analyses were conducted using the computer program, sequential oligogenic linkage analysis routines (SOLAR), version 4.0 [ 50].
Therefore SVY routines (Stata Version 10 Software) for handling correlated data were utilised to estimate proportions and 95% confidence intervals of women who had obstructed labour and its outcomes (perinatal death and maternal complications).
