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Treatment effect, i.e. presence of hyperplasia or not, was obtained after consensus between two different pathologists (AØ, who is a gynaecological pathologist, and one routine pathologist).
For both tumour origin and histologic type of differentiation, the prospective registrations were reevaluated independently by two experienced pathologists, a routine pathologist (ST) and a senior pathologist (OPFC).
However, while the routine pathologist who reevaluated the microscopic slides was blinded towards clinical and macroscopic data, the senior pathologist not only reevaluated the microscopic slides but also considered information from the operative and macroscopic reports.
Interobserver agreement between the senior and routine pathologist was almost perfect (kappa 0.90; 95% CI 0.82 0.99) for determination of histologic type of differentiation, while it was only fair (kappa 0.37; 95% CI 0.25 0.49) in classification of tumour origin.
The routine pathologist reviewed only the microscopic slides and was blinded towards clinical and macroscopic data, while the senior pathologist also considered this information when determining the anatomic site of tumour origin.
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For this reason, it is routine for pathologists to examine multiple sections from the same tumour, but to report only the highest grade.
In determining the cause of death in most routine autopsies, a pathologist offers his or her "best medical opinion".
Prospectively, the proposed model will be very beneficial in routine exam, providing pathologists with efficient and – as we will prove – effective second opinion for breast cancer grading from whole slide images.
The second parameter was considered as a second appraisal following routine diagnosis by pathologists.
The daily routine work of pathologists includes several hours of microscope and computer work [ 3].
Numerous potential health hazards are associated with the routine work of pathologists, but publications on this topic are rare and often decades old [ 2- 11].
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CEO of Professional Science Editing for Scientists @ prosciediting.com