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Based on its technical limitations, there is little reason to apply CGH to chromosomes of metaphase cells in routine diagnostic settings.
MinVar was designed to be compatible with a diverse range of sequencing platforms and allows the detection of DRMs and insertions/deletions from deep sequencing data without the need to perform additional bioinformatics analysis, a prerequisite to a widespread implementation of HIV-1 genotyping using deep sequencing in routine diagnostic settings.
In routine diagnostic settings, it might become necessary to postpone analysis or reevaluate previously evaluated samples of SF DNA in order to reconfirm or simply repeat results.
Cross-platform approaches, meaning generation of the training-set on a remote microarray set-up, different from the one locally used for analysing new samples, were demonstrated to be more consistent and reproducible than previously assumed (Nilsson et al, 2006), which further qualifies GEP to play a key role in routine diagnostic settings.
Preliminary data suggest that the proportion of X4 viruses beyond 5% (between 1% and 10%) may have a clinical impact, but not below this threshold, and therefore deeper exploration may not be needed in terms of clinical application in routine diagnostic settings.
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Thus, the single-round and multiplex PCR method offers a simple tool for the differential diagnosis of B. caballi and B. equi infections in routine diagnostic laboratory settings as well as in epidemiological studies.
As we have used an established, validated assay protocol that has been used in routine diagnostic and research settings for many years [ 14], we expect that autoantibody positive sera would have been detected in our experiments.
Therefore these tests must be evaluated in parallel before their implementations for routine diagnostic purposes in specific laboratory settings.
Background: Routine diagnostic laboratories are confronted with an ever-increasing workload with limited resources.
As F-FDG PET/CT will be more frequently used as a screening tool in more complex diagnostic settings like fever and inflammation of unknown origin, a routine investigator-independent strategy for establishing the diagnosis of LVV is needed.
In clinical settings where mycobacterial cultures are not part of the routine diagnostic work-up, all or most patients who report with suggestive symptoms but have negative smears are expected to be evaluated clinically.
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