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Then, a VRP representation of this operation was created, and new routes generated by a Tabu Search optimization procedure.
The proposed hybridization scheme extends the one of Pirkwieser and Raidl [14] who iteratively solve a set covering problem on the routes generated by a variable neighborhood search algorithm which works on complete solutions.
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We measure the SF for each route generated by CSR in our simulation.
We also study the stretch factor (SF) of CSR by measuring the SF of each route generated by CSR in our simulation.
First set is composed by circular routes, generated solving a travelling salesman problem (TSP) connecting the highest demand node pairs in the area with the stop of main transit network.
In our approach, a large neighborhood search algorithm works on complete solutions and additional routes are generated by a variable neighborhood search based heuristic column generator, relying on dual information.
In the first stage, all the feasible routes are generated by means of an implicit enumeration algorithm; afterwards, an integer programming model is designed to select in the second stage the optimum routes from the set of feasible routes.
Three parameters are used to evaluate the route sets generated by the proposed algorithm.
The different probabilities of gene activation by these routes generate a hierarchy of antigen-type expression during infections, contributing to the progressive waves of parasitemia characteristic of trypanosome infection (Gjini et al., 2010; Lythgoe et al., 2007).
Our observation suggests that major transition states may exist even though there are divergent routes of reprogramming generated by diverse reprogramming perturbations.
The gathering interest in the Northern Sea Route is being generated by a political as well as a physical thaw.
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