The cumulative effect actually makes Kennedy appear quite senior by comparison, but the group occasionally looked less like a Congressional campaign staff than a group of college students en route to a model congress.
A visual and intuitive route to describing models with an associated mathematical framework enables realisation in a software interface and integration with standard mathematical tools such as those for sensitivity analysis and parameter estimation.
Although model-based approaches (e.g. [ 54]) to gene tree reconciliation offer a direct route to incorporate models of sample bias into the problem, these are computationally expensive methods, and it may be possible to use faster weighting schemes in some modification of the GTP framework.
This approach, coupled with high speed automated experimental synthesis and characterization technologies now appearing, is the fastest route to developing models that regulatory bodies may find useful.
This chapter focuses on chaos and discusses the route-to-chaos model.
The route to linking different model types is highlighted as a major challenge and requires further research to establish its viability.
The simultaneous development of methods for reprogramming adult cells into induced pluripotent stem cells (iPSCs; Takahashi et al, 2007; Yu et al, 2007; Park et al, 2008) and the directed differentiation of pluripotent stem cells into distinct neuronal subtypes (Williams et al, 2012) suggested an attractive route to a novel model system for the study of neurological disorders.
In contrast to inferring model parameters, this work uses inverse modeling to obtain corrective, spatially distributed functional terms, offering a route to directly address model-form errors.
The discovery of these drugs provided a route to developing animal models to predict efficacy of novel antidepressants resulting in the first 'animal models of depression': reserpine-induced behavioural deficits (Askew, 1963) and immobility in the forced swim test (FST; Porsolt et al., 1977).
Although this prediction offers a route to differentiate between Models I and II, it may prove difficult to distinguish a labeled patch close to the injection site from the local axonal arbors of labeled cells.
