Further, rapamycin diminishes a range of aged-related pathologies (reviewed by Johnson et al., 2013b), and despite a contentious study claiming that it does not (Neff et al., 2013), the wide consensus is that appropriate modulation of mTOR signalling could be an important route of intervention to slow aging and increase healthspan (reviewed by Johnson et al., 2013a).
While circumstantial, these data clearly implicate the "obese" gut microbes as a contributing factor in human obesity and may also suggest novel routes of intervention in the battle against this health epidemic.
The ability of standing genetic variation in wild isolates of C. elegans to independently modify the age of onset, the cell type-specific susceptibility to protein aggregation, and several independent toxicity correlates of the polyglutamine expansion, suggests not only multiple paths to the expression of toxicity, but also multiple potential routes of intervention.
Numbers of animals, CKD model, follow-up, dosage, administration route, timing of intervention and outcome measures were all adequately reported.
This study was conducted to compare the efficacy and safety of both routes of nutritional intervention.
Here, we start from the known modalities to regulate YAP/TAZ to highlight possible routes of therapeutic intervention.
In this study, we aimed to find a combination of tests to characterise dormancy mechanisms in breast cancer patients, which would enable possible routes of therapeutic intervention.
Patients treated with GP IIb/IIIa inhibitors were significantly more likely to undergo the procedure via the femoral route, receive intervention of the LAD, and have multivessel intervention.
Intervention level clinical variables include: Dose/strength/intensity of treatment, duration of treatment, brand/manufacturer, co-interventions, timing, route of administration, compliance, clinician training, and implementation [ 1, 2, 4, 5, 8, 12].
Similar results were obtained if we preserved the timing of intervention but modified the route of drug administration switching to a continuous infusion, Figure 8.
Such subgroups would include comparisons of data of the same dose and route of administration of the same experimental intervention, with the same control intervention (for instance, a placebo), and reporting on the same emesis endpoint (for instance vomiting) during the same observation period (for instance late success).
