The overall route of change is called the course of the reaction, and the detailed process by which the change occurs is referred to as the reaction path or pathway.
Given that the great majority (typically, around 90%) of nucleotide substitutions in evolving microbial genomes are silent [ 64, 74], and even among those that affect protein sequences many are effectively neutral, it seems indisputable that rapid gene flux is the most important route of change in prokaryotic evolution.
For many patients, gallbladder disease and its accompanying symptoms are preventable, but you wouldn't know it from the patients whose parents prefer to book the quick fix of the scalpel instead of the slow, but less invasive, route of lifestyle change.
Mr McKinney said that decision "might have to come from as far up as the Northern Ireland Executive, because it went down the route of pension changes and reform".
This sort of dynamic fate mapping provides complex data sets with information that can be quantitatively mined for EC positions and divisions, speed and route of movement, changes in nuclear shape and spacing that provides an overall, quantitative perspective of their interactions (Fig. 3).
In addition to treatment with specific medications, side effects can be also managed with dose alteration, change in the route of administration, or change to other opioid formulation.
"I had a paper route and a pocketful of change with nowhere to put it but pinball machines".
Even if you tried to plot out your life like it's a Google Map route, the mercurial tides of change are bound to take you in a direction you hadn't expected.
As the route of your journey changes, you may need a new road map.
The route of administration also changed significantly: after implementation, more patients received medication p.o. (comparable with the difference in the administered acetaminophen).
Nicorandil and isosorbide mononitrate were also administered after surgery, and the route of administration was changed to oral and transdermal patches, respectively, on postoperative day 3.
