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In mammalian cells, the principal route for detoxification of this reactive metabolite is via the glutathione-dependent glyoxalase pathway forming d-lactate, involving lactoylglutathione lyase (GLO1; EC 4.4.1.5) and hydroxyacylglutathione hydrolase (GLO2; EC 3.2.1.6).
Although a number of pioneering works have been reported on treatment of arsenic containing wastewater by various techniques, only a few studies on a microbial route for detoxification of arsenic has been reported so far.
This data indicates that L. donovani mutants probably have a significantly reduced rate of metabolism of MG as compared to the wild-type parasites suggesting that the glyoxalase pathway is the dominant route for detoxification of MG in L. donovani.
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The accumulation of ascorbate and H2O2 along the tonoplast and in vacuoles during these conditions indicates an important route for H2O2 detoxification under these conditions.
GSTP1 (glutathione S-transferase pi) is a major route of detoxification of platinum agents.
The existing data support the conclusion that lower doses of methyl eugenol and other allyl alkoxy-benzenes undergo O-demethylation as the primary route of detoxification.
Determine if ZIP14 at the BL membrane of enterocytes provides an alternate route for systemic Mn detoxification.
Major routes of detoxification of both contaminants included cytochrome P-450-mediated ring hydroxylation at the C-5 position followed by conjugation to glucuronic or sulfuric acid.
This finding of Jensen et al. (2004) fits nicely with the fact that glutathione conjugation in particular is known to be a major detoxification route for PAs.
The drug is no substitute for detoxification.
Genes responsive to tobacco smoke were enriched for detoxification functions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com