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Besides smaller issues which can be targeted in clinical trials (patient selection, administration route, dosing, timing of administration), one major obstacle hampers the initiation of large, controlled trials using MSCs in infants and other patients: No standardized, high-quality cell product is available to test in clinical studies.
23, 34 We chose the delivery route, dosing, and treatment regimens for EC based on previous work 22– 26, 26, 34, 35 and our preliminary tests.
By this sophisticated software, pharmacists could see patient information, including age, diagnosis, allergy history, body weight, pregnancy status, clinical laboratory data (eg, blood glucose levels), and drug information, such as approved drug name, dose, administration route, dosing frequency, and the list of all current medications, all such information visually displays in the same interface.
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33 In conclusion, the experts preferred the oral route, dosed according to the recommendation, with a possible switch to parenteral in case of an insufficient response at the highest tolerable dose.
If you look closely at the tricky language of the sentence you will see that changes to biologics that result in new indications, routes, dosing schedules, delivery systems, strengths, etc., are ineligible for another 12- year exclusivity period under the Eshoo approach only if they come about without a modification to the structure of the product.
The anti-peptide antibody response against f1.K/B2.1 was optimized for the injection route, dose and adjuvant.
The immunization procedure of DNA vaccine pcDNA TA4 IL-2 of Eimeria tenella, including route, dose, time of immunization and age of primary immunization of chicken, was optimized.
The hydrochloride salt of (26g) showed 84.26 ± 4.44percentt inhibition at 50 mg/kg × 5 days (twice daily, oral route) dose in L. donovani/hamster model.
However, the optimal route, dose and duration of PPI therapy after endoscopic therapy remain controversial.
31 In this study, administration conditions were varied with respect to route, dose, concentration and volume.
Aspects of use examined included indications, route, dose, dilution, diluent and compatibility.
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