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Although there is no evidence that perturbation of the endosomal route contributes to the clearance of MHC I proteins from the cell surface, HCMV appears to perturb the same endosomal routes of other cellular proteins as MCMV.
Several studies have shown that deregulation of STAT3, Akt, and ERK signaling is implicated in tumorigenesis [ 34- 39], suggesting that aberrant activity of a network of interrelated signaling pathways, rather than a single deregulated route, contributes to carcinogenesis.
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There was no official list of riders kept by the express company and the scarcity of newspapers along the route contributed to the absence of this information.
In the 1980s, concerns about oil spills along the whales' migratory route contributed to the decision to place a moratorium on oil and gas leasing off the California coast.
The pRGCs are in turn innervated indirectly by the rods and cones and via this route contribute to SCN light activation [ 28 31].
It usually occurs via the hematogenic and the lymphogenic metastasis routes [ 4, 5], and the latter is considered to be a very important route contributing to metastasis of solid tumors [ 6].
28 While water-based hypotheses are attractive because Campylobacter is common in natural waters, the general absence of geographically located point-source outbreaks would be inconsistent with this transmission route contributing to seasonality.
Various transmission routes contribute to spread of carbapenem-resistant Klebsiella pneumoniae (CRKP) in hospitalized patients.
However, we can anticipate that both hematogenous and cell-mediated (eg by migrating dendritic cells) routes contribute to this process.
This information will open new routes contributing to the dissection of WRKY signal transduction pathways in plants.
Therefore, it is likely that both the MyD88-Traf6-dependent pathway and parallel MyD88-independent signalling routes contribute to the infection-induced expression of miR-146.
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