In those fights, Pacquiao has boxed 317 rounds, and he need look no further than his own corner, where his trainer, Freddie Roach, has Parkinson's disease, to see the effects of repeated pounding.
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Such patients are sent no further invitations to take part in further FOB testing rounds until they leave surveillance.
Cells were imaged every 5 or 10 s at ×20 magnification until cells became rounded with no further apparent change in spread area, and after some delay, eventually detached.
Populations were recursively clustered by pooling the pair of populations or clusters that yielded the minimum non-significant ΦST at each round until no further insignificant clustering (i.e. minimum ΦST P > 0.05) was possible (Roewer et al. 2005; Mascheretti et al. 2008, 2009).
Following this round, it was evident that no further rounds were required as there was sufficient coherence in participants' responses.
This was tested in round 2, and no further problems emerged.
For the overall study after round 2, we have defined the point at which the study is ceased and there are no further rounds (see figure 2).
After round two, similar beliefs and ideas were repeated and no major problems emerged, and thus we decided no further rounds were required.
FIA president Max Mosley later announced "The disruption caused embarrassment and inconvenience to those presenting the trophies and therefore, no further rounds of the FIA Formula 1 World Championship will be held at the Jerez circuit".
