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Sanyo expects sales in the United States to jump roughly fourfold over the next two years.
That same year WHO also recorded a roughly fourfold increase in polio cases in Nigeria, from 11 the previous year to more than 40, raising concerns that the disease might spread rapidly to high-risk countries; the cause for the increase was unclear.
The scientists saw "a roughly fourfold increase" in sperm abnormalities and a 50% decrease in sperm count after 1 month of treatment, Blake says.
For the basic growth scenario, global annual cobalt demand increases from 50 kt/yr in 2007 to 110 kt/y in 2030 and 190 kt/yr in 2050, which is a roughly fourfold increase over the modeling period (Fig. 2).
By contrast, humans have accumulated mutations that disrupt genes encoding olfactory receptors at rates roughly fourfold higher than in the great apes and other primates [88].
The PK/PD analysis of study data yielded an EC50 value roughly fourfold lower than the respective TCZ one, a less steep slope for the exposure response curve and an effect compartment rate constant roughly fourfold lower.
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The viscosity of cytoplasm is roughly the same as pure water, although diffusion of small molecules through this liquid is about fourfold slower than in pure water, due mostly to collisions with the large numbers of macromolecules in the cytosol.
On the other hand, when neutral mutations are roughly equally as likely as favored ones (i.e., Nes less than 1), repeatability decreases much more, by around fourfold for equal probabilities (to 1.9% and 1.4%).
SecondMarket, the leading trading exchange handling transactions in these securities, is expected to execute about $400 million in trades across about 40 private companies this year, roughly a fourfold increase over 2009, the first year it began making markets in the companies, according to a company spokesman.
Prior to implementation, students' SAT-Math scores were a highly significant correlate of course success (Odds Ratio 1.78 7.69, p < 0.001), such that an increase of one standard deviation correlated with roughly a nearly fourfold increase in the likelihood of a student earning a B-minus or better in the course.
Kristensen and colleagues [ 13] and subsequently others found a roughly twofold to fourfold elevated risk in relation to certain numbers of CYP19 TTTA repeat polymorphisms.
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