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15 genetic modifiers of the rough eye phenotype were isolated.
Overexpression of MblC in the fly eye precursors led to an externally rough eye morphology.
We do note, however, a rough eye phenotype in vps36 mosaics (Fig. 5D).
Therefore, we sought to understand the developmental underpinnings of the CagA-induced adult "rough" eye phenotype.
Altogether 23 lines that modified the rough eye phenotype were recovered in the EP screen.
These spz mutations had no apparent effect on the rough eye phenotype as heterozygotes (not shown).
The Aβ42 effects are quantified by the severity of the rough eye phenotype, as previously [23].
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In the cnn/+ heterozygous background to reduce the Cnn level, the rough-eye phenotype of GMR>Baz was strongly enhanced.
Furthermore, we found dTAK1-triggered rough-eye phenotype remained unaffected by the loss of Wnd.
Compared with the driver-alone control, wild-type tau produced a reduced, rough-eye phenotype (Fig. 3A).
In contrast, the rough-eye phenotypes can be suppressed by introducing a single copy of a UAS-dE2f1 + transgene.
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