Exact(1)
My only quibble is that from the start her voice is quaky and uncertain, leaving little room for escalation in her performance.
Similar(7)
Limited room for dose escalation due to limited drug loading b.
And that gives us no room for additional escalation".
With regard to a future dose escalation study, it has to be stated that a 2 mCi/kg (LBM) starting dose for the first cohort is at the lower end of the range of administered activity in our patients (Table 1 of Supplementary information) and provides room for a reasonable escalation of the subsequent cohorts and/or multiple doses of I-MIP-1095.
Among non-de-escalated patients, an initial broad-spectrum antibiotherapy could have been stepped down in 17: thus, there is clear room for improving the rate of de-escalation.
McNamara are in no mood for escalation.
But the capacity for escalation has not gone away.
But the pressure for escalation will continue to mount.
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Justyna Jupowicz-Kozak
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