Reflecting on the Roles of Class and Gender: How did social class conventions play out during the disaster?
Class I Arfs (Arf1 Arf3) are involved in the recruitment of membrane-budding machineries, whereas the roles of Class II Arfs (Arf4 and Arf5) remain unclear.
The aim of this review is to summarise recent advances in understanding the diverse developmental roles of Class I HDACs as components of distinct protein complexes.
However, the distinct biological roles of class I HDACs and HDAC6 strongly suggest that the selectivity profile of HDAC inhibitors may have major consequences on their clinical activity.
To better understand the roles of class Ib molecules, we have characterized their gene duplication, organization and expression patterns within the H2 region of the mouse strain C57BL/6.
Future work should be dedicated to uncovering the enzymatic activities and roles of Class II SDH gene products in plant metabolism.
All three classes are expressed in P. aeruginosa, though at very different levels, and there are indications for different roles of class I and class II during different cell cycle phases.
By using the class II-specific HDAC inhibitor MC1568, we separated class I- and class II-dependent effects and defined the roles of class II enzymes in muscle differentiation in cultured cells and in vivo.
Also, deletion of PDE1 in C. albicans changed the level of expression of genes, stress responses, cell wall and membrane biogenesis, adherence, and virulence, suggesting irreplaceable roles of class II PDEs in stress, adhesion, and virulence.
During the past years, a number of mouse loss-of-function studies provided new insights into the individual roles of class I deacetylases in cell cycle control, differentiation and tumorigenesis.
