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Since Y. pestis adapted to intra-dermal transmission by flea bites while the two others enter their host via the oral route, it seems logical to speculate that YadA plays an essential role in the early stages of the oral infection but no such role was demonstrated so far.
In our patient, Rickettsia's pathogenic role was demonstrated by PCR, a technique that has previously enabled us to identify other arthropod-borne Rickettsia species (8, 9 ).
The expansin gene studied in this work is involved in the destabilization of the cellulose-hemicellulose network and its role was demonstrated by Brummell et al. [ 26].
Among the alterations affecting cell growth and differentiation mechanisms, a key pathogenetic role was demonstrated for NOTCH1-activating mutation, detectable in about 60% of the cases, with or without associated FBXW7 gene inactivation.
It is not surprising that PAX8 knockdown results in significant loss in A549 cell viability; as such a role was demonstrated for PAX transcription factors including PAX8 in the promotion of cancer cell growth [ 12, 24, 25].
In our patient, its pathogenic role was demonstrated by PCR, a technique that has also proven useful in identifying other new rickettsial diseases, including infections with R. helvetica (5), R. slovaca (6), and R. felis (7).
Similar(53)
This central role is demonstrated by the orientation of this region in the crystallized sirtuins.
In summary, a critical role is demonstrated for GATA3 within the networks that govern breast cancer progression.
An example of this dual role is demonstrated through the enhancement of c-Src kinase activity in OKP cells within 1.5 minute after acid loading [ 21].
The starch molecules such as amylopectin, amylose and intermediate materials, the non-starch molecules such as bound phosphates and lipids, and the crystal dimensions etc. their roles were demonstrated in the architectures of blocklet and granular ultrastructure.
Similar functional roles were demonstrated of external oblique and internal oblique abdominal muscles during isometric axial rotation [ 20, 21].
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Justyna Jupowicz-Kozak
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