Exact(1)
Other losers in the longer term include local authorities, which saw their education role trimmed again, through a review of school spending efficiency and a proposal for a national school funding formula designed to end the regional patchwork that sees funding vary by thousands of pounds per pupil.
Similar(59)
ERAP1 plays a critical role in trimming peptides to the optimal length for HLA class I presentation [20] and cleaving cell surface receptors for proinflammatory cytokines.
The recent discovery of the anti-HIV activity of TRIM5α in primate cells has stimulated much interest in the potential role of TRIM proteins in antiviral activities and innate immunity.
These data suggest that SLX4 might play a role in trimming telomeres to prevent overlengthening.
It may play a role in trimming peptides, in the endoplasmic reticulum, for binding to HLA class I molecules where they are transported to the cell surface for presentation to T cells.
The presence of platelet-derived bioactive substances such as plasminogen activator inhibitor-1, tissue inhibitor of metalloproteinases-1, vascular endothelial growth factor and tissue factor, in platelet concentrates, may play an important role in TRIM [ 7].
The role of trimming by Nbr on miRNA function has been assessed with the study of miR-34 upon expression of a catalytically mutant form of nbr in cultured cells, where miR-34 silencing was compromised by ∼20% (Han et al., 2011).
Mr. Lochbaum, too, dared to suggest that public relations had played a role in the trim, although the plant's public relations man, Peter Hyde, held fast to his denials.
ERAP1 plays a role in peptide trimming in the generation of most HLA (human leukocyte antigen) class I binding peptides, and is also involved in regulating proinflammatory cytokine signaling through cleavage of cytokine cell surface receptors.
Our evolutionary screen to identify novel restriction factors reveals several intriguing candidates that warrant further study to fully elucidate the role played by TRIM genes either directly or indirectly in mediating antiviral defense.
Recently, the endoplasmic reticulum aminopeptidase 2 (ERaproteolyticenzymec enzyme set in the endoplasmic reticulum (ER) has been shown to co-localize with EpCAM in the cytoplasm/ER where it plays a central role in the trimming of peptides for presentation by MHC class I molecules.
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