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Although its strong conservation and high abundance indicate an important cellular role, the function of the vault is unknown.
It has long been known that human mt-mRNA can be polyadenylated (3), but even after numerous attempts to determine its exact role, the function of this modification is still unclear.
As part of this role, the function of the highly extended D/E-rich domain in midasin could be to interact with positively-charged nuclear protein substrates in a manner analogous to the acidic regions of the nuclear transport GTPase Ran [ 51], the nuclear transporter Tpr [ 52], and the chromatin remodeling proteins of the SWI/SNF family [ 53].
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It plays important roles in the functions of brain, gastrointestinal tract, cardiovascular system, and immune cells.
We developed an antisense strategy using hammerhead ribozymes against this gene to understand the roles and the functions of BRCA1.
The functions of these roles are described below.
They play little role in the functioning of the legitimate economy, yet a crucial role in the underground economy.
Women have always played a critical role in the functioning of societies.
Though physically small, microbes play a large role in the functioning of global ecosystems.
Duarte, C. M., Agustí, S. & Regaudie-de-Gioux, A. In The Role of Marine Biota in the Functioning of the Biosphere (ed. Duarte, C. M.) 39 54 (Fundación BBVA, Bilbao, 2011).
Bistable systems play an important role in the functioning of living cells.
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