Many helicases have been implicated to play role in these processes, however their detail roles, specificities and co-operativity in the complex protein-protein interaction networks remain unclear.
In the present paper, we review the conformational differences between free and bound TCRs, quantifying the structural changes that occur and discussing their possible roles in specificity and cross-reactivity.
By acknowledging their role and specificities, and by providing them with adapted guidance, the international Good Clinical Practices codes would provide valuable guidance and support to non-commercial clinical research, whose relevance for global health is increasingly evident.
It is therefore important to determine the pathogenic role and specificity of anti-class I and class II HLA and non-HLA-DSA and to better understand the effect of de novo DSA compared with preexisting DSA.
Despite its putative role in malignancy the specificity and exact role of the human enzyme remains unclear.
It is clear that TM3 and TM7 of TAS2R16 play a key role in receptor specificity and activation.
Helicity was proved to play a crucial role on peptide specificity and biological activities.
We believe that peptide helicity plays an important role on the specificity and the toxicity of antimicrobial peptides.
Current evidence suggests that these accessory subunits play an important role in the specificity and activity of the catalytic subunits [2].
The FM cluster has been shown to play an important role in antigenic specificity and expression of flagellar structures in Campylobacter species.
In these rhizobia, NolX (also referred to as NopX) has been shown to play a role in nodulation specificity and is exclusively expressed during the early stages of interactions with plants [ 25, 26].
