However the possible roles of wild type Cbl proteins in apoptosis remain less clear.
However, KRAS mutations are identified in less than half of all colon cancers, and the role of wild-type KRAS in the hypoxic response is less certain.
In a previous work, we confirmed the protective role of wild-type N-terminus Htt [ 22].
We next assessed the role of wild-type or SKAP55 KO or ADAP KO CD8+ CTLs to suppress tumor growth.
Truncated and mutant forms ofp53 affect life span in Drosophila, nematodes and mice, however the role of wild-type p53 in aging remains unclear.
The role of wild-type (wt) TP53 in tumor suppression is strongly linked to the molecular properties of the p53 protein.
The simulations in Wang et al. preserve the large structural change observed in the mutant while probing the role of wild-type side chain chemistry in that context.
To assess any essential role of wild-type huntingtin in this cell stress response, we treated STHdh mCerulean cofilin cell lines with specific small interfering ribonucleic acid (siRNA) to knockdown levels of huntingtin.
To characterize the role of wild-type Ank and its mutants in the regulation of PPi transport in vitro, we stably transduced ATDC5 cells with wild-type Ank and three missense mutations we have reported in families with familial chondrocalcinosis.
Our results show that BRAF plays a major role in the proliferation of thyroid carcinoma cells independently of the oncogenic activation, suggesting a role of wild-type BRAF also in RET/PTC and activated RAS signalling pathways.
