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(For different interpretations and evaluations of the role of this model in Aristotle, see Hintikka 1973, Sorabji 1980, Seel 1982, Waterlow 1982a, van Rijen 1989, Gaskin 1995).
The predictive role of this model has been successfully validated, with some modifications, by a retrospective analysis that included 353 patients with mRCC at the Cleveland Clinic (Mekhail et al, 2005).
These recent discoveries not only advance our understanding of important physiological mechanisms in the fruit fly, they also expand the role of this model organism to include conserved molecular mechanisms of carbohydrate homeostasis in animals.
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Building upon the physiological functions of Drp1 identified here, the Drp1cKO model can now be used to elucidate the role of this protein in models of neurological disorders that target the hippocampus.
CD40L does not play a role in this model of antibody-mediated TRALI.
C3 does not seem to have a major role in this model of joint inflammation.
We therefore conclude that PD-1 plays a non-redundant role in this model of CD4+ T cell tolerance.
Cytokines, especially IL-17 and TNF-α, also play an important role in this model of arthritis [ 25, 26].
Expression of integrins in Tgfbr2-cKO is under current investigation to exploit a putative role in this model of TGFβ-dependent angiogenesis.
The CAST allele at Gct6 plays a tumor suppressor role in this model of reproductive cancer that is dependent upon endrocrine signaling.
It is assumed that acid/pepsin plays a major pathogenic role in this model of esophagitis; PGs derived from COX-1 are involved in mucosal defense of the esophagus; and some amino acids are protective against esophagitis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com