Sentence examples for role of this complex from inspiring English sources
The fact that silencing of kibra and expanded also shifted the lethal phenotype observed upon glial-specific snr1 knockdown and caused reversal of the CNS phenotype, supports an unfavourable role of this complex under conditions of reduced snr1 expression.
The recognition of the central role of this complex in intracellular proteolysis in turn fuelled an intense quest for novel compounds with both increased selectivity towards the proteasome and better bioavailability that could be used in fundamental research or in the clinic.
These features prompted us to investigate the role of this complex during centriole duplication initiation and elongation in RPE-1 cells by RNA interference experiments and nocodazole treatment.
The present findings causally correlate androgen activation of Rac 1 to the upstream AR/FlnA/integrin beta 1 complex, further pointing to the key role of this complex in hormonal action.
We hope that with an increasing focus on reliable methods to type beta-defensin copy number variation we will be in a position to investigate the role of this complex locus in disease.
Understanding the functional role of this complex in Drosophila provides only partial information needed to explain its evolution.
It is clear, however, that in ookinetes GAP45 can fulfill its structural role outside of this complex, which may serve primarily to deliver and anchor MyoA and MTIP to their location in the supra-alveolar space.
This system provides a platform for examining the role of this mechanosensory complex in the pathology of myotonic and muscular dystrophies, peripheral neuropathy, and spasticity inducing diseases like Parkinson's.
These findings support a role of this intracellular complex in the systemic inflammation of RA.
We have identified a novel role of this multiprotein complex in maintaining heterochromatin integrity at subtelomeres and heterochromatin islands.
The role of this muscle complex is to produce and control tensions in response to changes in intraabdominal pressure.
