Sentence examples for role of this class from inspiring English sources

Treatment with cabozantinib, a third-generation TKI, resulted in improved survival in two clinical studies, indicating the important role of this class of agents in the treatment of these patients79.

Starting from a discussion about the importance and role of this class of measurements, the authors show the architecture of an image-based measurement system and introduce the important issue of the related uncertainty then coming to investigate models and methods for evaluating it.

Notably, 4 out of the 5 genes coding for ns-Hbs (OsNSHB1-4) and the putative HbO-encoding gene were up-regulated in 24 h-treated roots only in Eurosis, suggesting a possible role of this class of molecules in the differential response of the two genotypes to the treatment.

Studies also suggests role of this class of kinase in regulation of transcription of numerous genes in bacterium [90].

Recently, Wallace and Felsenfeld proposed that the enhancer-blocking activity of cHS4 might be a corollary of a wider role of this class of elements in organizing large scale structures within the nucleus [14].

While many components of the RNAi pathway appear to be missing from the B. malayi genome, most notably the spreading machinery [11], presence of ego-1 suggests conservation of the role of this class of RNA-directed RNA polymerases in germline silencing across Nematoda.

Finally, the presence of the "79-bp signature" in a large proportion of the SIDER2 elements may be suggestive of a transcriptional role for this class of repeats.

Here we demonstrate that poxviruses additionally utilize PI3K at several distinct stages of morphogenesis, including early and late gene expression, late protein trafficking and envelopment, and maturation of virions, suggesting a much broader role for this class of host molecules than has been previously recognized.

Experimental investigations of these proteins have provided insights into the diverse roles of this class of innate immunity proteins in host defence and inflammatory diseases.

We not only identified this enrichment, but also an enrichment upstream of exons exhibiting splicing changes in CNS, which is in line with known roles of this class of splicing factors in neuronal disease mutations.

Together, these findings point to a general role for this class of compounds in mediating a wide variety of signaling cascades, and suggest that their metabolism by E. lenta may have much broader consequences than are currently appreciated.