To examine the role of allergic sensitization in the association between phthalate metabolites and asthma, we fitted additional models after stratification by allergic sensitization.
Based on the crucial role of behavioral sensitization in drug addiction, it is necessary to investigate the effect of baclofen on morphine-induced behavioral sensitization which can also provide new insights into the understanding of potential mechanism underlying the morphine dependence.
Our study suggests the role of central sensitization of the vestibular nuclei in the patients with preexisting pathology of the vestibular system in VM pathogenesis.
The presence of widespread pressure pain hypersensitivity in distant pain-free areas in TTH supports the role of central sensitization [8, 9].
In the current study, we showed that children with CTTH pain showed larger muscle referred pain areas in head, neck and shoulder muscle TrP as compared to healthy children, supporting a plausible role of central sensitization in muscle referred pain.
The role of allergic sensitization to Ascaris in the development of wheeze, independent of atopy, requires further investigation.
A few small studies have provided support for the role of central sensitization in pain augmentation among RA patients.
Several studies have shown a crucial role of TLR4 in sensitization to aeroallergens (1, 7, 10, 13, 27, 40) and especially in sensitization to rDer p 2 (9) via the bronchoepithelial route.
In previous work, sumatriptan did not change P-CREB induced by forskolin in cultured neurons taken from adult rat trigeminal ganglions, nor inhibit CGRP release at the same model, as may expected [8], although the role of CGRP on sensitization is unclear [17].
A key role of tumor cell sensitization to immune attack is supported by the role of TRAIL in tumor resolution and explains the paradox of successful CD8 T cell-dependent anti-tumor responses in the absence of CD8 T cell expansion.
