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Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging.
In general the authors who have concerned themselves with the role of replication in selection strive to liberate our thinking from the hold that genes and organisms have over us.
Additionally, in light of the emerging important role of replication stress in the early stages of cancer development, our findings may provide a mechanism for the role of NHEJ in preventing tumorigenesis.
In light of the crucial role of replication stress at the early stages of cancer development, our results suggest that the impaired response to replication stress could be the mechanism by which defective NHEJ contributes to human carcinogenesis.
This conclusion of a major role of replication errors in the generation of spontaneous mutations in vivo is further strengthened by our present finding of an increased mutation load in those parts of the brain, i.e., hippocampus and hypothalamus, that are known centers of neurogenesis.
This is consistent with a role of replication fork reversal in the prevention CAG·CTG repeat instability.
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Several data suggest a role of replication-fork components in the establishment of sister chromatid cohesion.
The role of replications in this process will be highlighted.
There is no way around the crucial role of replications (both exact and conceptual, i.e., in different contexts, with different populations, different behaviours, etc). in advancing psychological theory.
To separate the roles of replication and transcription in the expansion of Friedreich's ataxia (GAA)n repeats, we designed two yeast genetic systems that utilize a galactose-inducible GAL1 promoter but contain these repeats in either the transcribed or nontranscribed region of a selectable cassette.
63, 64 There has been debate and even controversy about the relative roles of replication versus neogenesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com