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Therefore, anthrapyrazoles have thus far not fulfilled the role of replacing doxorubicin as an active DNA intercalator with minimal or no cardiotoxicity.
The FAST was a factorial trial in first-line treatment of advanced non-small-cell lung cancer (NSCLC), addressing the role of replacing cisplatin with a non-platinum agent.
The FAST is a 2 × 2 factorial trial addressing two questions: (1) the role of replacing cisplatin (P) with a non-platinum agent, vinorelbine (N), and (2) the role of adding a third agent, ifosfamide (I), in a doublet based on gemcitabine (G).
Considering this background, a randomised 2 × 2 factorial phase III trial addressing two questions: (1) the role of replacing cisplatin (P) with a non-platinum agent, vinorelbine (N), and (2) the role of adding a third agent, ifosfamide (I), in a chemotherapy doublet based on gemcitabine (G) was performed.
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Moreover, this chapter discusses the role and impact of replacing steel with lighter engineering materials and how decision-making tools can act as a framework for eco-material selection.
At the last minute Jay Hunter Morris took over the role of Siegfried, replacing the ailing Gary Lehman.
Mr. Kobborg will dance the role of Albrecht, replacing Maxim Beloserkovsky, who is injured.
Elsewhere, Cartoon Network filled the role of upstart, replacing Saturday morning with Monday night as a haven for cartoons aimed at children, especially boys.
EMERSON ELECTRIC CO., St . Louis a maker of electric motors, said its chief executive, David Farr, would take on the added role of chairman, replacing Charles Knight, who is retiring after 32 years.
Molecular dynamics computer simulations show the important role of oxygen replacing nitrogen at surface sites in the prismatic surface of β-Si3N4 on the adsorption of rare-earth ions from the intergranular film.
Late in rehearsals for the original production, Jessie Bond assumed the role of Hebe, replacing Mrs Howard Paul.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com