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"Future research should explore the role of dose, timing, and route of triclosan exposure," the paper's authors wrote.
The role of dose rate and oxygen diffusion in determining the extent of change is discussed.
We subsequently explored the role of dose interval and circadian time for irinotecan oxaliplatin combination.
These hypotheses highlight the role of dose and schedule and have significantly influenced oncology practice.
This pilot study evaluated the role of dose escalation and appropriate target volume margin.
We next investigated the role of dose and time in radiation-induced upregulation of HER2.
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One prospective study investigating the role of dose-dense chemotherapy in patients with early breast cancer has demonstrated that epoetin alfa had no adverse influence on survival (Möbus et al, 2004).
Experiments 3 and 4 tested the role of dosing time of irinotecan – oxaliplatin combination.
The role of dosing time upon single agent irinotecan or oxaliplatin activity was investigated in experiments 1 and 2 respectively.
Although this wide range of in vivo efficacy mainly depends on substantial heterogeneity of illness severity, the role of dosing regimen must be taken into account.
In order to demonstrate how the model can be used to investigate the role of dosing protocol on clinical outcomes, dose-matched administrations of sclerostin mAb were simulated at several dosing intervals.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com