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The role of complement in post-ischemic cerebral injury is incompletely understood.
Yet, the role of complement activation in this setting is unknown.
The African Green Monkey (AGM) model was used to analyze the role of complement in neutralization of parainfluenza virus.
sCR1 has been shown experimentally to be effective in reducing hyperacute rejection in xenotransplantation highlighting the role of complement in graft rejection [83].
This minireview briefly examines the role of complement in neurological diseases and outlines the current status of the development of key neurological nanomedicines with respect to complement activation.
The studies support the role of complement activation and erythrophagocytosis in the pathogenesis of anaemia in falciparum malaria in African children.
The role of complement in processes of neurodegeneration in the injured or aged and diseased central nervous system is well known.
Although the critical role of complement component C3d as a molecular adjuvant in preventing virus infection is well established, its role in cancer therapies is unclear.
Most of the evidence for the role of complement in preventing systemic damage comes from experimental data obtained in these studies in which the addition of complement inhibitors blocks or reduces damage [49].
To investigate the role of complement factor H (CFH) I62V (rs800292) and age-related maculopathy susceptibility 2 (ARMS2) A69S (rs10490924) variants in the clinical characteristics of polypoidal choroidal vasculopathy (PCV).
IxACs may also be used as tools to investigate the role of complement activation in certain diseases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com