To investigate the role of ATM in BC susceptibility, we studied 76 rare sequence variants in the ATM gene in a case-control family study of 2,570 cases of breast cancer and 1,448 controls.
Therefore, further investigation into the mechanisms underlying Bmi-1 down-regulation in Atm-/ NSCs is necessary to better understand the role of ATM in regulating self-renewal and proliferation of NSCs.
As ATM that has pivotal roles in DNA damage-induced responses is necessary for YAP accumulation, we investigated the role of ATM in Chaetocin-mediated YAP1 induction.
Zhou, K. et al. The role of ATM in response to metformin treatment and activation of AMPK.
Shan Zha, MD, PhD, Institute for Cancer Genetics, will receive $1,900,000 over five years from the National Cancer Institute for "The Role of ATM in Suppression of Lymphomas" in a competitive renewal.
Previous studies have identified a significant role of ATM in the maintenance of HSCs and immune systems.
To more directly assess the role of ATM and/or ATR, shRNAs were utilized.
However, it is not clear whether the role of ATM in DNA repair is solely responsible for A-T pathogenesis.
Although the precise role of ATM in A-T pathogenesis is still unclear, its function in responding to DNA damage has been well established.
The role of ATM in tumor suppression is solidly established and attributed, at least in part, to its well-known function in DNA damage repair.
Here we provide evidence for a novel role of ATM in mitochondrial biogenesis through AMPK activation in response to etoposide-induced DNA damage.
