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This role may be mediated by Treg up-regulation by LL.
The data, therefore, suggest that VEGF may act as an autocrine growth factor for mammary cancer cells in vivo and this autocrine regulatory role may be mediated through flk-1.
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Alternatively, the connection between the peripheral and central role of STX1A may be mediated by immune-nervous system interactions involving both CD4+ and CD8+ lymphocytes that express STX1A and enter the central nervous system [42].
The regulation may be due to a direct transcriptional role of Sry or it may be mediated by sex hormones; the latter is supported by research indicating that XY complement-induced differences in immune response might be suppressed in the presence of testosterone [ 77].
Overexpression of Bcl-xL counteracts LC3-II increase, contributing to the hypothesis that the protective role of Bcl-xL observed in some SMA models may be mediated by its role in autophagy inhibition.
The gaseous components appear to play an important role in the proarrhythmic response, which may be mediated by activation of TRPA1, and subsequent sympathetic modulation.
We hypothesize that the cleavage-independent stimulatory role of Drosha on gene expression may be mediated through its association with protein cofactors.
Other observations suggest that the role of arsenic as a cocarcinogen may be mediated by inhibition of DNA repair and increased expression of cyclin D1 (Vogt and Rossman 2001).
Taken together, our data suggest that the proinflammatory and procarcinogenic role played by COX-2 in response to UVR, may be mediated, in part, by upstream NFAT signaling.
Taken together, these data suggest that the proinflammatory and procarcinogenic role played by COX-2 in response to UVR may be mediated, in part, by upstream NFAT signaling.
Thus, the role of LRRC25 should be crucial and may be mediated through the "closet" ITIM, which is usually employed in promoting appropriate immune cell behavior, i.e., LRRC25 may regulate subtly myeloid cell development or inflammatory responses as an adjustable switch.
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CEO of Professional Science Editing for Scientists @ prosciediting.com