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Furthermore, although ChRs conserve residues from BR, including the homologues to Asp85, the proton acceptor and primary counterion to the Schiff base (SB), and Asp212, which is also located near the SB and believed to exist in a negative form at neutral pH (see Figure 1), their role may be different in ChRs.
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Distinct cellular responses may be mediated by the intrinsic chromatin status and unique sets of TFs, and the factors that play the most important roles may be different depending on cell type.
This additional role of Sdh3 may be different at the two different growth conditions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com