It wasn't enough to save him from 10 months in federal prison, two years of probation and a $10,000 fine, but James Tobin the once high-ranking GOP official convicted for his role in jamming Democratic phone banks on Election Day 2002 attracted legions of admirers from all walks of life.
Some moths produce ultrasonic clicks that were once thought to have a role in jamming bat echolocation.
In line with this approach, previous work from our laboratory investigated the role of JAM-C in neural functions using JAM-C-KO mice (13).
Through the use of JAM-C-deficient mice and/or blocking antibodies, the role of JAM-C has been investigated in numerous disease models such as models of arthritis (12), peritonitis (13), acute pancreatitis (14), ischemia-reperfusion injury (11), and pulmonary inflammation (15, 16).
To investigate the role of JAM-C in neuronal functions further, mice with a specific deletion of JAM-C in SCs (JAM-C SC KO) were generated.
Our previous investigations into the role of JAM-A in breast cancer had analyzed levels of JAM-A expression in two cohorts of patients with invasive breast cancer.
Although these results suggest that JAM-C is involved in leukocyte recruitment during inflammation, the role of JAM-C in human inflammatory diseases has not been well studied.
As the latter remains the only published work to date reporting on the role of JAM-C in SCs, to further investigate the functions of JAM-C in nerves here we report on the generation of a novel mouse colony in which JAM-C is deleted selectively in SCs, JAM-C SC KO.
However, as the severe and complex phenotype of the complete JAM-C-KO mice makes the study of the functional role of JAM-C in nerves difficult, to extend our previous works we now report on the generation and investigations of a novel mouse colony in which the expression of JAM-C is selectively deleted in SCs.
To investigate a potential role for JAM-C in arthritis, we tested the effect of the monoclonal anti-JAM-C antibody H36 [ 17] on the course of AIA.
